6-Chloropurine

Zouping Jinxing Chemical Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm 6-chloropurine hauv Suav teb. Yog hais tias koj yuav mus rau cov lag luam wholesale bulk 6-chloropurine ua nyob rau hauv Suav teb, txais tos kom tau txais cov qauv dawb los ntawm peb lub hoobkas. Tag nrho cov khoom customized yog nrog cov khoom zoo thiab tus nqi qis.

Cov tsos mob: Dawb mus rau daj ntseg daj / txiv kab ntxwv - daj crystalline hmoov (dawb ntawm purity siab dua; nyiam daj me ntsis thaum raug lub teeb)
Melting point: >300℃(decomposition); cov ntaub ntawv feem ntau hais txog 300-305℃(dec.); tsis muaj qhov sib txawv atmospheric boiling point
Boiling point (kwv yees): kwv yees li . 449.6 ± 25.0℃/ 760 mmHg (nrog rau decomposition)
Qhov ceev: Kwv yees li . 1.65 g / cm³ (20 degree; kwv yees tus nqi hauv 1.46–1.70 ntau yam tshwm sim hauv cov ntaub ntawv)
Solubility: Dej ~ 5 g / L (20 degree); Soluble hauv dej kub, DMF, DMSO (~ 30 mg / mL), thiab dilute alkaline daws; sparingly soluble hauv ethanol thiab diethyl ether; λ max 264 nm (0.1 M HCl, ε ≈ 8700)
pKa: Predicted 7.47 ± 0.20 (kev hloov pauv nrog purine N-protonation/deprotonation)

Pharmaceutical intermediates (core): Rau zus tau tej cov adenine (ntawm amination), 6-mercaptopurine (ntawm thiolation; leukemia tshuaj), thioguanine, nucleoside analogues (antiviral / antitumor agents), thiab immunosuppressant sab chains
Nucleic acid tsev blocks: 9-alkylpurines, hloov purine ligands, fluorescent sojntsuam precursors
Kev tshawb fawb biochemical: Kev tshawb fawb ntawm purine antimetabolite mechanisms (inhibition ntawm HGPRT, blockade ntawm IMP → AMP / GMP txoj kev)

Toxicity: Tsawg rau nruab nrab toxicity. Qhov ncauj LD₅₀ (nas) ≈ 720 mg/kg; intraperitoneal LD₅₀ (rat) ≈ 400 mg/kg.
GHS: GHS07 (Ceeb toom); H302 (Kev phom sij yog tias nqos tau); R22/R36/37/38 (Irritating rau qhov muag, ua pa, thiab tawv nqaij); WGK 3 (muaj kev phom sij heev rau dej).
Kev tuav: Siv N95 plua plav daim npog qhov ncauj, tsom iav kev nyab xeeb, thiab hnab looj tes nitrile; hnyav rau hauv lub hood fume thiab tsis txhob nqus plua plav.
Cia thiab Thauj: Khaws kaw, tiv thaiv lub teeb, thiab qhuav ntawm 2–8℃(ntev -) lossis nyob rau hauv chav tsev kub; cais raws li tsis yog- phom sij rau kev thauj mus los (NONH), tab sis khaws cia cais los ntawm cov neeg muaj zog oxidizing.

Cim npe nrov: Tuam Tshoj 6-chloropurine manufacturers, lwm tus neeg, Hoobkas